Cloning and expression of P450c17-I (17α-hydroxylase/17,20-lyase) in brain and ovary during gonad development in Cynoglossus semilaevis

@article{Chen2009CloningAE,
  title={Cloning and expression of P450c17-I (17α-hydroxylase/17,20-lyase) in brain and ovary during gonad development in Cynoglossus semilaevis},
  author={Cai Fang Chen and Haishen Wen and Zhao Peng Wang and Feng He and Jia Rui Zhang and Xiao Yong Chen and Guo Xiong Jin and Bao J Shi and Dan Shi and Yan P. Yang and Ji F. Li and Bao X. Qi and Na Li},
  journal={Fish Physiology and Biochemistry},
  year={2009},
  volume={36},
  pages={1001-1012}
}
Cytochrome P450c17 (CYP17, 17a-hydroxylase/17,20-lyase) is a critical enzyme in the production of androgens and estrogens in vertebrates. A 2,469 bp full length cDNA of P450c17-I (CYP17A1) has been isolated from the ovary of half-smooth tongue sole, Cynoglossus semilaevis which encodes 509 amino acids. Additionally, a relatively shorter cDNA (1,742 bp), a likely result of polyadenylation, was also found. The putative P450c17-I enzyme shares high sequence identity with that of the fathead minnow… CONTINUE READING

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