Cloning and elucidation of the FR901464 gene cluster revealing a complex acyltransferase-less polyketide synthase using glycerate as starter units.

@article{Zhang2011CloningAE,
  title={Cloning and elucidation of the FR901464 gene cluster revealing a complex acyltransferase-less polyketide synthase using glycerate as starter units.},
  author={Feng Zhang and Hai-Yan He and Man-cheng Tang and Yu-Min Tang and Qiang Zhou and Gong-Li Tang},
  journal={Journal of the American Chemical Society},
  year={2011},
  volume={133 8},
  pages={2452-62}
}
FR901464, an antitumor natural product, represents a new class of potent anticancer small molecules targeting spliceosome and inhibiting both splicing and nuclear retention of pre-mRNA. Herein we describe the biosynthetic gene cluster of FR901464, identified by degenerate primer PCR amplification of a gene encoding the 3-hydroxy-3-methylglutaryl-CoA synthase (HCS) postulated to be involved in the biosynthesis of a β-branched polyketide from Pseudomonas sp. No. 2663. This cluster consists of… CONTINUE READING

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