Cloning and developmental analysis of murid spermatid-specific thioredoxin-2 (SPTRX-2), a novel sperm fibrous sheath protein and autoantigen.

@article{MirandaVizuete2003CloningAD,
  title={Cloning and developmental analysis of murid spermatid-specific thioredoxin-2 (SPTRX-2), a novel sperm fibrous sheath protein and autoantigen.},
  author={Antonio Miranda-Vizuete and Katie Tsang and Yonghao Yu and Alberto Rodr{\'i}guez Jim{\'e}nez and M. Pelto-huikko and Charles J. Flickinger and Peter Sutovsky and Richard J. Oko},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 45},
  pages={
          44874-85
        }
}
Thioredoxins compose a growing family of proteins that participate in different cellular processes via redox-mediated reactions. We report here the cloning, developmental expression, and location of murid Sptrx-2. Mouse and rat SPTRX-2 proteins display a high homology to their human ortholog in the thioredoxin and NDP kinase domains, and the coding genes are located at syntenic positions. Northern blotting and in situ hybridization confirmed the testis-specific expression of murine Sptrx-2 mRNA… CONTINUE READING
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