Cloning and characterization of two members of the vertebrate Dlx gene family.

@article{Simeone1994CloningAC,
  title={Cloning and characterization of two members of the vertebrate Dlx gene family.},
  author={A. Simeone and D. Acampora and M. Pannese and M. D'Esposito and A. Stornaiuolo and M. Gulisano and A. Mallamaci and K. Kastury and T. Druck and K. Huebner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 6},
  pages={
          2250-4
        }
}
  • A. Simeone, D. Acampora, +7 authors K. Huebner
  • Published 1994
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
A number of vertebrate genes of the Dlx gene family have been cloned in mouse, frog, and zebrafish. These genes contain a homeobox related to that of Distalless, a gene expressed in the developing head and limbs of Drosophila embryos. We cloned and studied the expression of two members of this family, which we named Dlx5 and Dlx6, in human and mouse. The two human genes, DLX5 and DLX6, are closely linked in an inverted convergent configuration in a region of chromosome 7, at 7q22. Similarly… Expand
Differential expression of orthologous Dlx genes in zebrafish and mice: implications for the evolution of the Dlx homeobox gene family.
TLDR
Dlx expression patterns at early stages are better conserved between paralogous pairs of physically linked genes than between orthologous pairs, suggesting that early expression of Dlx genes existed prior to the duplications that led to the multiple pairs of physical linked genes but was differentially conserved in different paralogs in zebrafish and mice. Expand
Cross-interactions between two members of the Dlx family of homeobox-containing genes during zebrafish development.
TLDR
Dlx4 is one of the target genes of dlx3 in embryos and that cross-regulatory interactions between Dlx genes may beone of the mechanisms responsible for their overlapping expression, according to cotransfection experiments. Expand
Multiple functions of Dlx genes.
TLDR
Dlx genes comprise a highly conserved family of homeobox genes homologous to the distal-less (Dll) gene of Drosophila that seem to have multiple functions at different stages of development or in different tissues and cell types. Expand
A Highly Conserved Enhancer in the Dlx5/Dlx6Intergenic Region is the Site of Cross-Regulatory Interactions betweenDlx Genes in the Embryonic Forebrain
TLDR
It is proposed that the Dlx genes are part of a highly conserved developmental pathway that regulates forebrain development and is supported by cotransfection and DNA-protein binding experiments. Expand
Functions of Dlx genes 619 Multiple functions of Dlx genes
Dlx genes comprise a highly conserved family of homeobox genes homologous to the distal-less (Dll) gene of Drosophila. They are thought to act as transcription factors. All Dlx genes are expressed inExpand
Gene expression pattern Identification and developmental expression of three Distal-less homeobox containing genes in the ascidian Ciona intestinalis
TLDR
The isolation and characterization of another member of the ascidian family of Dll-related genes, which is tentatively named Ci-Dll-C, suggests that, during the evolution of the Chordate phylum, the Dlx genes arose from an ancestral Dll/Dlx gene via gene duplication. Expand
The Dlx genes as clues to vertebrate genomics and craniofacial evolution.
TLDR
This review provides an overview of the Dlx gene phylogeny with an emphasis on the chordate lineage, and supports the previous speculation that the nested DlX expression in the pharyngeal arch is likely a shared feature among all the extant jawed vertebrates. Expand
Expression of murine Lhx5 suggests a role in specifying the forebrain
  • H. Sheng, S. Bertuzzi, +4 authors H. Westphal
  • Biology, Medicine
  • Developmental dynamics : an official publication of the American Association of Anatomists
  • 1997
TLDR
The early, persistent, and dynamic expression of Lhx5 suggests a regulatory function in forebrain formation and this may represent a step of early regionalization of the forebrain. Expand
Identification and developmental expression of three Distal-less homeobox containing genes in the ascidian Ciona intestinalis
TLDR
The isolation and characterization of another member of the ascidian family of Dll-related genes, which is tentatively named Ci-Dll-C, suggests that, during the evolution of the Chordate phylum, the Dlx genes arose from an ancestral Dll/Dlx gene via gene duplication. Expand
Dlx5, the mouse homologue of the human-imprinted DLX5 gene, is biallelically expressed in the mouse brain
TLDR
It is suggested that the Dlx5 gene escapes genomic imprinting, at least in mice of certain genetic backgrounds. Expand
...
1
2
3
4
5
...

References

SHOWING 1-2 OF 2 REFERENCES
The mouse Dlx-2 (Tes-1) gene is expressed in spatially restricted domains of the forebrain, face and limbs in midgestation mouse embryos
The pattern of RNA expression of the murine Dlx-2 (Tes-1) homeobox gene is described in embryos ranging in age from E8.5 through E11.5. Dlx-2 is a vertebrate homologue of the Drosophila Distal-lessExpand
Characterization of human bone marrow‐derived closed circular DNA clones
Because of interest in mechanisms of recombination involved in chromosomal deletions in neoplastic disease, and their relation to possible rearrangements in normal tissues, we are studying circularExpand