Cloning and characterization of two members of the vertebrate Dlx gene family.

  title={Cloning and characterization of two members of the vertebrate Dlx gene family.},
  author={Antonio Simeone and Dario Acampora and Maria Pannese and Maurizio D'Esposito and Anna Stornaiuolo and Massimo Gulisano and Antonio Mallamaci and Kumar Kastury and Teresa Druck and Kay F Huebner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={91 6},
A number of vertebrate genes of the Dlx gene family have been cloned in mouse, frog, and zebrafish. These genes contain a homeobox related to that of Distalless, a gene expressed in the developing head and limbs of Drosophila embryos. We cloned and studied the expression of two members of this family, which we named Dlx5 and Dlx6, in human and mouse. The two human genes, DLX5 and DLX6, are closely linked in an inverted convergent configuration in a region of chromosome 7, at 7q22. Similarly… CONTINUE READING
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