Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans.

@article{MorimotoTomita2002CloningAC,
  title={Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans.},
  author={Megumi Morimoto-Tomita and Kenji Uchimura and Zena Werb and Stefan Hemmerich and S D Rosen},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 51},
  pages={
          49175-85
        }
}
Here we report the cloning of a full-length cDNA encoding the human ortholog (HSulf-1) of the developmentally regulated putative sulfatases QSulf-1 (Dhoot, G. K., Gustafsson, M. K., Ai, X., Sun, W., Standiford, D. M., and Emerson, C. P., Jr. (2001) Science 293, 1663-1666) and RSulfFP1 (Ohto, T., Uchida, H., Yamazaki, H., Keino-Masu, K., Matsui, A., and Masu, M. (2002) Genes Cells 7, 173-185) as well as a cDNA encoding a closely related protein, designated HSulf-2. We have also obtained cDNAs… CONTINUE READING
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