Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene.

@article{Horikawa1999CloningAC,
  title={Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene.},
  author={Izumi Horikawa and P LouAnn Cable and Cynthia A. Afshari and Jeffrey C. Barrett},
  journal={Cancer research},
  year={1999},
  volume={59 4},
  pages={826-30}
}
Activation of telomerase is one of the rate-limiting steps in human cell immortalization and carcinogenesis Human telomerase is composed of at least two protein subunits and an RNA component. Regulation of expression of the catalytic subunit, human telomerase reverse transcriptase (hTERT), is suggested as the major determinant of the enzymatic activity. We report here the cloning and characterization of the 5'-regulatory region of the hTERT gene. The highly GC-rich content of the 5' end of the… CONTINUE READING
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Expression profile of the putative catalytic subunit of the telomerase gene

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