Cloning and characterization of the murine promoter for the colony-stimulating factor-1-encoding gene.

@article{Harrington1991CloningAC,
  title={Cloning and characterization of the murine promoter for the colony-stimulating factor-1-encoding gene.},
  author={Maureen Harrington and Howard J. Edenberg and Scott Saxman and L M Pedigo and R Daub and Hal E. Broxmeyer},
  journal={Gene},
  year={1991},
  volume={102 2},
  pages={165-70}
}
Colony-stimulating factor-1 (CSF-1 or M-CSF) is required for the growth and differentiation of macrophage progenitors, and for the survival of mature macrophages. Expression of the CSF-1 gene in monocytes and fibroblasts is controlled at both the transcriptional and post-transcriptional levels. To study the molecular mechanisms which mediate changes in CSF-1 expression, the 5' promoter region of the mouse CSF-1 gene was cloned. A high degree of structural and sequence similarity between the… CONTINUE READING

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