Cloning and characterization of the bovine MHC class I-like Fc receptor.

@article{Kacskovics2000CloningAC,
  title={Cloning and characterization of the bovine MHC class I-like Fc receptor.},
  author={Imre Kacskovics and Zhaoting Wu and Neil E. Simister and L{\'a}szl{\'o} Vilmos Freny{\'o} and Lennart Hammarstr{\"o}m},
  journal={Journal of immunology},
  year={2000},
  volume={164 4},
  pages={
          1889-97
        }
}
In the cow, maternal immunity is exclusively mediated by colostral Igs, but the receptor responsible for the IgG transport has not yet been identified. The role of an IgG-Fc receptor (FcRn) that resembles a class I MHC Ag in transporting IgGs through epithelial cells was recently shown in selected species. We now report the cloning and characterization of the bovine FcRn (bFcRn). The cDNA and deduced amino acid sequences show high similarity to the FcRn in other species, and it consists of… CONTINUE READING

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