Cloning and characterization of the Xenopus cyclin-dependent kinase inhibitor p27XIC1.

@article{Su1995CloningAC,
  title={Cloning and characterization of the Xenopus cyclin-dependent kinase inhibitor p27XIC1.},
  author={Judy Y. Su and Rachel E Rempel and Eleanor Erikson and James L. Maller},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 22},
  pages={10187-91}
}
We have isolated a gene encoding Xic-1, a 27-kDa cyclin-dependent kinase (Cdk) inhibitor from Xenopus ovary that shares significant homology with both mammalian CIP1 and Kip1/Kip2. The N- and C-terminal halves of Xic-1 are sufficient for interacting with Cdks and proliferating cell nuclear antigen, respectively. Recombinant Xic-1 inhibits Xenopus cyclin E/Cdk2, cyclin A/Cdk2 and cyclin B/Cdc2 activities, although with quite different IC50 values. Truncation of the N terminus of Xic-1 increases… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 33 extracted citations

Similar Papers

Loading similar papers…