Cloning and characterization of the Pseudomonas aeruginosa lasR gene, a transcriptional activator of elastase expression.

Abstract

We report the discovery of the lasR gene, which positively regulates elastase expression in Pseudomonas aeruginosa PAO1. The lasR gene was cloned by its ability to restore a positive elastase phenotype in strain PA103, a strain which possesses the elastase structural gene (lasB) but fails to synthesize the enzyme. Nucleotide sequence analysis revealed an… (More)

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@article{Gambello1991CloningAC, title={Cloning and characterization of the Pseudomonas aeruginosa lasR gene, a transcriptional activator of elastase expression.}, author={Micheal J Gambello and Barbara H. Iglewski}, journal={Journal of bacteriology}, year={1991}, volume={173 9}, pages={3000-9} }