Cloning and characterization of the L-cysteine desulfhydrase gene of Fusobacterium nucleatum.

@article{Fukamachi2002CloningAC,
  title={Cloning and characterization of the L-cysteine desulfhydrase gene of Fusobacterium nucleatum.},
  author={Haruka Fukamachi and Yoshio Nakano and Mamiko Yoshimura and Toshihiko Koga},
  journal={FEMS microbiology letters},
  year={2002},
  volume={215 1},
  pages={75-80}
}
Hydrogen sulfide and methyl mercaptan are the two major compounds associated with oral malodor. These compounds are highly toxic, and are thought to play an important role in periodontal disease. Fusobacterium nucleatum, an oral bacterium, produces large amounts of hydrogen sulfide from L-cysteine by the enzymatic action of L-cysteine desulfhydrase. We cloned and sequenced the cdl gene encoding L-cysteine desulfhydrase from F. nucleatum ATCC 10953, and revealed that the structural cdl gene… CONTINUE READING