Cloning and characterization of phospholipase D from rat brain.

  title={Cloning and characterization of phospholipase D from rat brain.},
  author={Sunmin Park and Joseph J. Provost and Chang Dae Bae and Wanting Tina Ho and John H. Exton},
  journal={The Journal of biological chemistry},
  volume={272 46},
The regulation of phospholipase D cloned from rat brain (rPLD) was examined in vivo and in vitro. The enzyme was a shorter splice variant of human phospholipase D 1 (Hammond, S. M., Altshuller, Y. M. , Sung, T.-C., Rudge, S. M., Rose, K., Engebrecht, J. A., Morris, A. J., and Frohman, M. A. (1995) J. Biol. Chem. 270, 29640-29643). Its expression in COS-7 cells led to increased phospholipase D (PLD) activity that was further stimulated by constitutively active V14RhoA. V14RhoA had no effect on… CONTINUE READING


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