Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH.

@article{Marinoni1997CloningAC,
  title={Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH.},
  author={J C Marinoni and Rabindra K. Roy and Wim Vermeulen and Pierre Miniou and Yves Lutz and Geert Weeda and T Seroz and Diego Luis Mengual G{\'o}mez and Jan H. J. Hoeijmakers and Jean Marc Egly},
  journal={The EMBO journal},
  year={1997},
  volume={16 5},
  pages={1093-102}
}
TFIIH is a multiprotein factor involved in transcription and DNA repair and is implicated in DNA repair/transcription deficiency disorders such as xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy. Eight out of the nine genes encoding the subunits forming TFIIH have already been cloned. We report here the identification, cDNA cloning and gene structure of the 52 kDa polypeptide and its homology with the yeast counterpart TFB2. This protein, along with p89/XPB, p62, p44 and p34… CONTINUE READING

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