Cloning and characterization of novel human SLC4A8 gene products encoding Na+-driven Cl-/HCO3(-) exchanger variants NDCBE-A, -C, and -D.

@article{Parker2008CloningAC,
  title={Cloning and characterization of novel human SLC4A8 gene products encoding Na+-driven Cl-/HCO3(-) exchanger variants NDCBE-A, -C, and -D.},
  author={Mark D. Parker and Patrice Bouyer and Christopher M. Daly and Walter F. Boron},
  journal={Physiological genomics},
  year={2008},
  volume={34 3},
  pages={
          265-76
        }
}
  • Mark D. Parker, Patrice Bouyer, +1 author Walter F. Boron
  • Published in Physiological genomics 2008
  • Biology, Medicine
  • The reported sequences of the human and mouse Na+-driven Cl-/HCO3(-) exchangers (NDCBEs) differ greatly in their extreme cytosolic COOH termini (Ct). In human NDCBE (NDCBE-B), a 17-amino acid (aa) sequence replaces 66 aa at the equivalent position in mouse NDCBE (NDCBE-A). We performed 5'- and 3'-rapid amplification of cDNA ends (RACE) on human brain cDNA, followed by PCR of full-length cDNAs to determine whether the human SLC4A8 gene was capable of producing the mouselike Ct sequence. Our… CONTINUE READING

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