Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors.

@article{YamamotoHino1994CloningAC,
  title={Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors.},
  author={Miki Yamamoto-Hino and Tomomi Sugiyama and Kunio Hikichi and M. G. Matt{\'e}i and Kiyoshi Hasegawa and Susumu Sekine and Kazuhiro Sakurada and Atsushi Miyawaki and Teiichi Furuichi and Mamoru Hasegawa},
  journal={Receptors & channels},
  year={1994},
  volume={2 1},
  pages={9-22}
}
We have cloned cDNAs coding for human type 2 and type 3 and part of type 1 inositol 1,4,5-trisphosphate receptors (IP3Rs). The complete nucleotide sequences for type 2 and type 3 receptors were determined and the pharmacological properties of the latter were characterized. Human type 2 and type 3 IP3Rs are 2701 amino acids and 2671 amino acids long, respectively, and have significant sequence homologies as well as structural similarities including the six membrane-spanning regions near the C… CONTINUE READING