Cloning and characterization of human karyopherin

  title={Cloning and characterization of human karyopherin},
  author={Nabeel R. Yaseen and G{\"u}nter Blobel},
Nuclear import of classical nuclear localization sequence-bearing proteins is mediated by karyopherin ayb1 heterodimers. A second nuclear import pathway, mediated by karyopherin b2 (transportin), recently was described for mRNA-binding proteins. Here we report the cloning and characterization of human karyopherin b3, which may be involved in a third pathway for nuclear import. Karyopherin b3 was localized mainly to the cytosol and the nucleus, particularly the nuclear rim. It bound to several… CONTINUE READING


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Yaseen and Blobel Proc

D. L. Mager, Freeman, 18 J.D.NucleicAcidsRes., 5301. 4456 Cell Biology
Natl. Acad. Sci. USA 94 • 1997
View 3 Excerpts
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Molecular Cloning: A Laboratory Manual (Cold

J. Sambrook, E. F. Fritsch, T. Maniatis
View 1 Excerpt

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