Cloning and characterization of human karyopherin

@inproceedings{Yaseen1997CloningAC,
  title={Cloning and characterization of human karyopherin},
  author={Nabeel R. Yaseen and G{\"u}nter Blobel},
  year={1997}
}
Nuclear import of classical nuclear localization sequence-bearing proteins is mediated by karyopherin ayb1 heterodimers. A second nuclear import pathway, mediated by karyopherin b2 (transportin), recently was described for mRNA-binding proteins. Here we report the cloning and characterization of human karyopherin b3, which may be involved in a third pathway for nuclear import. Karyopherin b3 was localized mainly to the cytosol and the nucleus, particularly the nuclear rim. It bound to several… CONTINUE READING

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