Cloning and characterization of human cathepsin L promoter.

  title={Cloning and characterization of human cathepsin L promoter.},
  author={Radhika Bakhshi and Ajay Goel and Puneet Seth and P Chhikara and Shyam Sunder Chauhan},
  volume={275 1},
Cathepsin L is a lysosomal cysteine protease, which is over-expressed and secreted by malignant cells. It is very potent in degrading collagen, elastin, laminin and other components of the basement membrane and, therefore, has been implicated in tumor invasion and metastasis. The structural portion of the human cathepsin L (hCATL) gene was cloned to elucidate its genomic organization (Chauhan et al., J. Biol. Chem. 218 (1993) 1039). In the present study, a 1.90 kb DNA fragment, containing 1825… CONTINUE READING