Cloning and characterization of histamine dehydrogenase from Nocardioides simplex.

@article{Limburg2005CloningAC,
  title={Cloning and characterization of histamine dehydrogenase from Nocardioides simplex.},
  author={Julian Limburg and Minae Mure and Judith P Klinman},
  journal={Archives of biochemistry and biophysics},
  year={2005},
  volume={436 1},
  pages={
          8-22
        }
}
Histamine dehydrogenase (NSHADH) can be isolated from cultures of Nocardioides simplex grown with histamine as the sole nitrogen source. A previous report suggested that NSHADH might contain the quinone cofactor tryptophan tryptophyl quinone (TTQ). Here, the hdh gene encoding NSHADH is cloned from the genomic DNA of N. simplex, and the isolated enzyme is subjected to a full spectroscopic characterization. Protein sequence alignment shows NSHADH to be related to trimethylamine dehydrogenase… CONTINUE READING
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