Cloning and characterization of four SIR genes of Saccharomyces cerevisiae.

@article{Ivy1986CloningAC,
  title={Cloning and characterization of four SIR genes of Saccharomyces cerevisiae.},
  author={J M Ivy and Amar J. S. Klar and James B. Hicks},
  journal={Molecular and cellular biology},
  year={1986},
  volume={6 2},
  pages={688-702}
}
Mating type in the yeast Saccharomyces cerevisiae is determined by the MAT (a or alpha) locus. HML and HMR, which usually contain copies of alpha and a mating type information, respectively, serve as donors in mating type interconversion and are under negative transcriptional control. Four trans-acting SIR (silent information regulator) loci are required for repression of transcription. A defect in any SIR gene results in expression of both HML and HMR. The four SIR genes were isolated from a… CONTINUE READING