Cloning and characterization of complementary DNA encoding the eukaryotic initiation factor 2-associated 67-kDa protein (p67).

@article{Wu1993CloningAC,
  title={Cloning and characterization of complementary DNA encoding the eukaryotic initiation factor 2-associated 67-kDa protein (p67).},
  author={Shan Wu and Sarita Gupta and Nanda Dulal Chatterjee and Ronald E. Hileman and Terri Goss Kinzy and Nancy D. Denslow and William C. Merrick and Debopam Chakrabarti and John C. Osterman and Naba K. Gupta},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 15},
  pages={
          10796-801
        }
}
The eukaryotic initiation factor 2 (eIF-2)-associated 67-kDa glycoprotein (p67) protects eIF-2 alpha-subunit from inhibitory phosphorylation by eIF-2 kinases, such as heme-regulated inhibitor and double-stranded RNA-activated inhibitor. This promotes protein synthesis in the presence of eIF-2 kinases present in animal cells (Ray, M. K., Datta, B., Chakraborty, A., Chattopadhyay, A., Meza-Keuthen, S., and Gupta, N. K. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 539-543). In this study, the primary… CONTINUE READING

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