Cloning and characterization of cDNAs for a bovine (Bos taurus) Mx protein.

  title={Cloning and characterization of cDNAs for a bovine (Bos taurus) Mx protein.},
  author={N M Ellinwood and Jesica McCue and Paul W Gordy and Richard A. Bowen},
  journal={Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research},
  volume={18 9},
Mx proteins are GTPases that are stringently induced in cells from many vertebrates on exposure to type I interferons (IFNs), and expression of some Mx proteins potently inhibits replication of specific viruses. Two cDNAs encoding bovine Mx proteins were isolated from an endometrial phage library. The open reading frames (ORFs) of these two clones predict proteins of 654 (Mxl) and 648 (Mxl-a) residues. Both possess the tripartite GTPase domains, dynamin signature, and leucine zipper motifs… CONTINUE READING
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