Cloning and characterization of a sub-family of human toll-like receptors: hTLR7, hTLR8 and hTLR9.

@article{Chuang2000CloningAC,
  title={Cloning and characterization of a sub-family of human toll-like receptors: hTLR7, hTLR8 and hTLR9.},
  author={T H Chuang and Richard J Ulevitch},
  journal={European cytokine network},
  year={2000},
  volume={11 3},
  pages={372-8}
}
Members of the Toll-like receptor family are essential components of the innate immune system. Herein we report the molecular cloning and characterization of three novel human Toll-like receptors (hTLRs) designated hTLR7, hTLR8, and hTLR9. Human TLR7-9, like the previously described members hTLR1-6 contain an ectodomain with multiple leucine-rich repeats (LRRs) and a cytoplasmic domain homologous to that of the human interleukin-1 (IL-1) receptor. When compared with hTLR1-6, the hTLR7-9 has a… CONTINUE READING
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