Cloning and characterization of a rat brain receptor that binds the endogenous neuromodulator gamma-hydroxybutyrate (GHB).

@article{Andriamampandry2003CloningAC,
  title={Cloning and characterization of a rat brain receptor that binds the endogenous neuromodulator gamma-hydroxybutyrate (GHB).},
  author={Christian Andriamampandry and Omar Taleb and Sandrine Viry and Claude P. Muller and Jean Paul Humbert and Serge Gobaille and Dominique Aunis and Michel Maitre},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2003},
  volume={17 12},
  pages={
          1691-3
        }
}
Gamma-hydroxybutyrate (GHB) is an endogenous neuromodulator with therapeutical applications in anesthesia, sleep disorders, and drug addiction. We report the cloning of a GHB receptor from a rat hippocampal cDNA library. This receptor has a molecular mass of 56 kDa and belongs to the seven-transmembrane receptor family. The peptidic sequence has no significant homology with any known receptor, including GABA(B) receptors. Its mRNA is restricted to the brain and is particularly abundant in the… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 38 CITATIONS

GHB receptor targets in the CNS: focus on high-affinity binding sites.

VIEW 4 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Cloning and functional characterization of a gamma-hydroxybutyrate receptor identified in the human brain.

VIEW 9 EXCERPTS
CITES BACKGROUND & METHODS

Narcolepsy and depression and the neurobiology of gammahydroxybutyrate

VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 50 REFERENCES