Cloning and characterization of a rat brain receptor that binds the endogenous neuromodulator γ‐hydroxybutyrate

@article{Andriamampandry2003CloningAC,
  title={Cloning and characterization of a rat brain receptor that binds the endogenous neuromodulator γ‐hydroxybutyrate},
  author={C. Andriamampandry and O. Taleb and Sandrine Viry and C. Muller and J. P. Humbert and S. Gobaille and D. Aunis and M. Maitre},
  journal={The FASEB Journal},
  year={2003},
  volume={17}
}
  • C. Andriamampandry, O. Taleb, +5 authors M. Maitre
  • Published 2003
  • Medicine, Biology
  • The FASEB Journal
  • γ‐Hydroxybutyrate (GHB) is an endogenous neuromodulator with therapeutical applications in anesthesia, sleep disorders, and drug addiction. We report the cloning of a GHB receptor from a rat hippocampal cDNA library. This receptor has a molecular mass of 56 kDa and belongs to the seven‐transmembrane receptor family. The peptidic sequence has no significant homology with any known receptor, including GABAB receptors. Its mRNA is restricted to the brain and is particularly abundant in the… CONTINUE READING
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