Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume.

@article{Waldegger1997CloningAC,
  title={Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume.},
  author={Siegfried Waldegger and Peter Barth and Gertraud Raber and Florian Lang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 9},
  pages={
          4440-5
        }
}
Hepatic metabolism and gene expression are among other regulatory mechanisms controlled by the cellular hydration state, which changes rapidly in response to anisotonicity, concentrative substrate uptake, oxidative stress, and under the influence of hormones such as insulin and glucagon. Differential screening for cell volume sensitive transcripts in a human hepatoma cell line revealed a gene for a putative serine/threonine kinase, h-sgk, which has 98% sequence identity to a serum- and… CONTINUE READING

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