Cloning and characterization of a novel member of the human Mad gene family (MADH6).


MAD (mothers against decapentaplegic)-related proteins (MADRs) are intracellular components that play critical roles in signal-transduction pathways involving the transforming growth factor beta (TGFbeta) superfamily. Some Mad genes are candidates for tumor-suppressor functions. From a human fetal brain cDNA library we have isolated a novel Mad-related gene. Two alternatively transcribed mRNAs encode deduced 430- and 467-amino-acid peptides that showed high levels of similarity to MADR1/Smad1/hMAD1 (about 80% identity at the amino acid level). This gene, which we designated MADH6, resides on 13q12-q14 between BRCA2 and RB, a region that frequently displays loss of heterozygosity in breast, liver, and prostate cancers.


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@article{Watanabe1997CloningAC, title={Cloning and characterization of a novel member of the human Mad gene family (MADH6).}, author={Takeshi Watanabe and M Suzuki and Yasue Omori and Haretugu Hishigaki and Maya Horie and N Kanemoto and Toshiyoshi Fujiwara and Yuji Nakamura and Eiji Takahashi}, journal={Genomics}, year={1997}, volume={42 3}, pages={446-51} }