Cloning and characterization of a novel member of the transforming growth factor-beta/bone morphogenetic protein family.

@article{Paralkar1998CloningAC,
  title={Cloning and characterization of a novel member of the transforming growth factor-beta/bone morphogenetic protein family.},
  author={Vishwas M. Paralkar and Amy L. Vail and William A. Grasser and Thomas A. Brown and Hong Xu and Slobodan Vuki{\vc}evi{\'c} and Hua Zhu Ke and Hong Xiu Qi and Thomas A. Owen and David A. Thompson},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 22},
  pages={13760-7}
}
Members of the transforming growth factor-beta (TGF-beta) superfamily of growth and differentiation factors have been identified in a wide variety of organisms, ranging from invertebrates to mammals. Bone morphogenetic proteins (BMPs) constitute a subgroup of proteins belonging to the TGF-beta superfamily. BMPs were initially identified by their ability to induce endochondral bone formation at ectopic sites, suggesting a critical role for this family in development and regeneration of the… CONTINUE READING