Cloning and characterization of a novel human dual flavin reductase.

  title={Cloning and characterization of a novel human dual flavin reductase.},
  author={Mark J. I. Paine and Andrew J P Garner and David Newell Powell and John Milne Alan Sibbald and Mark A Sales and Nicole Pratt and Tekla Smith and David G Tew and C. R. Wolf},
  journal={The Journal of biological chemistry},
  volume={275 2},
Flavoprotein reductases play a key role in electron transfer in many physiological processes. We have isolated a cDNA with strong sequence similarities to cytochrome P-450 reductase and nitric-oxide synthase. The cDNA encodes a protein of 597 amino acid residues with a predicted molecular mass of 67 kDa. Northern blot analysis identified a predicted transcript of 3.0 kilobase pairs as well as a larger transcript at 6.0 kilobase pairs, and the gene was mapped to chromosome 9q34.3 by fluorescence… CONTINUE READING
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