Cloning and characterization of a novel human pH‐dependent organic cation transporter, OCTN1

@article{Tamai1997CloningAC,
  title={Cloning and characterization of a novel human pH‐dependent organic cation transporter, OCTN1},
  author={I. Tamai and H. Yabuuchi and J. Nezu and Y. Sai and A. Oku and M. Shimane and A. Tsuji},
  journal={FEBS Letters},
  year={1997},
  volume={419}
}
cDNA for a novel proton/organic cation transporter, OCTN1, was cloned from human fetal liver and its transport activity was investigated. OCTN1 encodes a 551‐amino acid protein with 11 transmembrane domains and one nucleotide binding site motif. It is strongly expressed in kidney, trachea, bone marrow and fetal liver and in several human cancer cell lines, but not in adult liver. When expressed in HEK293 cells, OCTN1 exhibited saturable and pH‐dependent [3H]tetraethyl ammonium uptake with… Expand
Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations.
Molecular cloning and characterization of high-affinity carnitine transporter from rat intestine.
Functional Analysis of Organic Cation Transporter 3 Expressed in Human Placenta
Cloning and functional characterization of a novel up-regulator, cartregulin, of carnitine transporter, OCTN2.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 19 REFERENCES
cDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2.
Mechanisms of organic cation transport in kidney plasma membrane vesicles: 2. delta pH studies.
  • P. Holohan, C. Ross
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • 1981
pH sensitivity of H+/organic cation antiport system in rat renal brush-border membranes.
...
1
2
...