Cloning and characterization of a novel human 5-HT4 receptor variant that lacks the alternatively spliced carboxy terminal exon. RT-PCR distribution in human brain and periphery of multiple 5-HT4 receptor variants.

@article{Vilar2002CloningAC,
  title={Cloning and characterization of a novel human 5-HT4 receptor variant that lacks the alternatively spliced carboxy terminal exon. RT-PCR distribution in human brain and periphery of multiple 5-HT4 receptor variants.},
  author={Maria Teresa Vilar{\'o} and Teresa Dom{\'e}nech and Jos{\`e} Maria Palacios and Guadalupe Mengod},
  journal={Neuropharmacology},
  year={2002},
  volume={42 1},
  pages={60-73}
}
We have cloned a novel C-terminal splice variant of serotonin 5-HT4 receptors from human hippocampus. The deduced protein extends only one aminoacid past the splicing point. We propose to call the novel variant h5-HT4(n) since it contains none of the C-terminal exons alternatively spliced in other variants. The pharmacological profile of h5-HT4(n) stably expressed in HeLa cells is in agreement with other reported variants. Stably transfected cells showed increased basal levels of intracellular… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

Heterologous expression of functional G-protein-coupled receptors in Caenorhabditis elegans.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2012

Similar Papers

Loading similar papers…