Cloning and characterization of a novel NMDA receptor subunit NR3B: a dominant subunit that reduces calcium permeability.

@article{Matsuda2002CloningAC,
  title={Cloning and characterization of a novel NMDA receptor subunit NR3B: a dominant subunit that reduces calcium permeability.},
  author={Keiko Matsuda and Yoshinori Kamiya and S Matsuda and Michisuke Yuzaki},
  journal={Brain research. Molecular brain research},
  year={2002},
  volume={100 1-2},
  pages={43-52}
}
We report the cloning and characterization of a novel NMDA receptor subunit cDNA, which encodes a predicted polypeptide of 1003 amino acids. Phylogenic analysis indicates that this new subunit is most closely related to NR3A. Therefore, we term it NR3B. Important functional domains of glutamate receptors, such as the ligand-binding domain, the channel pore, and the channel gate, are conserved in NR3B. NR3B mRNA was expressed highly in pons, midbrain, medulla, and the spinal cord, but at low… CONTINUE READING

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