Corpus ID: 6167203

Cloning and characterization of a new armadillo family member, p0071, associated with the junctional plaque: evidence for a subfamily of closely related proteins.

@article{Hatzfeld1996CloningAC,
  title={Cloning and characterization of a new armadillo family member, p0071, associated with the junctional plaque: evidence for a subfamily of closely related proteins.},
  author={M. Hatzfeld and C. Nachtsheim},
  journal={Journal of cell science},
  year={1996},
  volume={109 ( Pt 11)},
  pages={
          2767-78
        }
}
Cell contacts of the adherens type are organized around transmembrane proteins of the cadherin family. Whereas the extracellular domains mediate homophilic interactions between cadherins of neighbouring cells the cytoplasmic domains organize a set of proteins into the junctional plaque. Among these junctional plaque proteins are members of the armadillo gene family, beta-catenin, plakoglobin (gamma-catenin), B6P/plakophilin and p120. These proteins are assumed to play a key role in cell cell… Expand
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TLDR
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TLDR
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The Armadillo Family Protein p0071 Is a VE-cadherin- and Desmoplakin-binding Protein*
TLDR
Findings suggest that p0071 may play an important role in endothelial junction assembly and in the morphogenic events associated with vascular remodeling. Expand
The p120 family of cell adhesion molecules.
  • M. Hatzfeld
  • Biology, Medicine
  • European journal of cell biology
  • 2005
TLDR
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TLDR
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Plakophilin 3--a novel cell-type-specific desmosomal plaque protein.
TLDR
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References

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The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties
TLDR
It was shown that beta-catenin and plakoglobin are distinct molecules, which can coexist in the same cell type, and anti-armadillo antibodies have been further used to determine the intracellular localization of beta-Catenin, and to examine its tissue distribution. Expand
Identification of Plakoglobin Domains Required for Association with N-cadherin and α-Catenin (*)
TLDR
Transfected carboxyl-terminal deletions of plakoglobin into the human fibrosarcoma HT-1080 are transfected and immunofluorescence localization and co-immunoprecipitation are used to map the regions ofplakoglobin that allow it to associate with N-cadherin and with α-catenin. Expand
Band 6 protein, a major constituent of desmosomes from stratified epithelia, is a novel member of the armadillo multigene family.
TLDR
The predicted amino acid sequence of human B6P shows strong sequence homology with a murine p120 protein, which is a substrate of protein tyrosine kinase receptors and of p60v-src, and raises the question of whether the structural proteins B 6P, plakoglobin, beta-catenin and armadillo share some function. Expand
p120, a p120-related protein (p100), and the cadherin/catenin complex
TLDR
It is shown that endothelial and epithelial cells express p120 and p100, a 100-kD, p120- related protein, which suggests that p120/p100 may participate in regulating the function of cadherins and, thereby, other processes influenced by cell-cell adhesion. Expand
A homolog of the armadillo protein in Drosophila (plakoglobin) associated with E-cadherin.
TLDR
The complementary DNA sequence was determined for the 92-kilodalton beta catenin of Xenopus laevis, a protein of desmosomal and zonula adherens cell junctions, and to the plakoglobin homolog in Drosophila melanogaster, the product of the segment polarity gene armadillo. Expand
p120, a novel substrate of protein tyrosine kinase receptors and of p60v-src, is related to cadherin-binding factors beta-catenin, plakoglobin and armadillo.
TLDR
A near full-length cDNA encoding murine p120 is isolated, which contains four copies of an imperfect 42 amino acid repeat that occurs 12.5 times in the protein encoded by Drosophila armadillo (arm), and its direct homologs, human plakoglobin and Xenopus laevis beta-catenin (beta-cat). Expand
Cell type-specific desmosomal plaque proteins of the plakoglobin family: plakophilin 1 (band 6 protein).
Desmosomes represent a special type of the plaque-bearing adhering junctions, characteristic of certain pathways of cell differentiation, which compositionally are not identical in the various kindsExpand
PF16 encodes a protein with armadillo repeats and localizes to a single microtubule of the central apparatus in Chlamydomonas flagella
TLDR
It is suggested that the PF16 gene product is involved in protein-protein interactions important for C1 central microtubule stability and flagellar motility. Expand
Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes.
p120cas is a tyrosine kinase substrate implicated in ligand-induced receptor signaling through the epidermal growth factor, platelet-derived growth factor, and colony-stimulating factor receptors andExpand
The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin
TLDR
Like beta-catenin and plakoglobin, CAS interacts directly with E-cadherin in vivo; however, unlike beta-Cateninand plakemia, CAS does not interact with APC or alpha-catanin. Expand
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