Cloning and characterization of a human STE20-like protein kinase with unusual cofactor requirements.

@article{Schinkmann1997CloningAC,
  title={Cloning and characterization of a human STE20-like protein kinase with unusual cofactor requirements.},
  author={Karin A Schinkmann and John Blenis},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 45},
  pages={28695-703}
}
We cloned and characterized a novel human member of the STE20 serine/threonine protein kinase family named mst-3. Based on its domain structure, mst-3 belongs to the SPS1 subgroup of STE20-like proteins, which includes germinal center (GC) kinase, hematopoietic progenitor kinase (HPK), kinase homologous to STE20/SPS-1 (KHS), kinases responsive to stress (KRS1/2), the mammalian STE20-like kinases (mst1/2), and the recently published STE20/oxidant stress response kinase SOK-1. mst-3 is most… CONTINUE READING

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