Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases
@article{Okano1998CloningAC, title={Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases}, author={Masaki Okano and Shaoping Xie and En Li}, journal={Nature Genetics}, year={1998}, volume={19}, pages={219-220} }
Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases
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The Balasubramanian laboratory is supported by core funding from Cancer Research UK (C14303/A17197) and the Wellcome Trust (Grant No. 099232/z/12/z).
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It is shown by two independent assay systems that the purified Dnmt2 protein has weak DNA methyltransferase activity, and methylation was observed at CG sites in a loose ttnCGga(g/a) consensus sequence, suggesting that DnMT2 has a more specialized role than other mammalian DNA methyl transferases.
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