Cloning and characterization of a calcium-sensing receptor from the hypercalcemic New Zealand white rabbit reveals unaltered responsiveness to extracellular calcium.

@article{Butters1997CloningAC,
  title={Cloning and characterization of a calcium-sensing receptor from the hypercalcemic New Zealand white rabbit reveals unaltered responsiveness to extracellular calcium.},
  author={Robert R Butters and Naibedya Chattopadhyay and Preben Berg Nielsen and Craig P Smith and Ambrish Mithal and Olga Kifor and M. Geetha Bai and S. D. P. Quinn and Paul Goldsmith and Shelley Hurwitz and K. Krapcho and John Busby and Edward Meigs Brown},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={1997},
  volume={12 4},
  pages={568-79}
}
The extracellular Ca2+ (Ca(0)2+)-sensing receptor (CaR) recently cloned from mammalian parathyroid, kidney, brain, and thyroid plays a central role in maintaining near constancy of Ca(0)2+. We previously showed that the hypercalcemia normally present in New Zealand white rabbits is associated with an elevated set point for Ca(02+)-regulated PTH release (the level of Ca(0)2+ half-maximally inhibiting hormonal secretion). This observation suggested an alteration in the Ca(02+)-sensing mechanism… CONTINUE READING