Cloning and characterization of a cDNA representing a putative complement-regulatory plasma protein from barred sand bass (Parablax neblifer).

@article{Dahmen1994CloningAC,
  title={Cloning and characterization of a cDNA representing a putative complement-regulatory plasma protein from barred sand bass (Parablax neblifer).},
  author={A. Dahmen and T. Kaidoh and P. Zipfel and I. Gigli},
  journal={The Biochemical journal},
  year={1994},
  volume={301 ( Pt 2)},
  pages={
          391-7
        }
}
It has been demonstrated previously that plasma from a number of vertebrate species including the phylogenetically old barred sand bass possesses molecules that cleave the alpha'-chain of the activated third (C3b) and fourth (C4b) components of the human complement system. A specific protease and a cofactor protein were identified to be responsible for this cleavage. The cofactor activity in sand bass correlated with a 110 kDa polypeptide chain of a 360 kDa plasma protein. The evolutionary… Expand
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