Cloning and characterization of TNKL, a member of tankyrase gene family

  title={Cloning and characterization of TNKL, a member of tankyrase gene family},
  author={AN Kuimov and DV Kuprash and V. F. Petrov and K K Vdovichenko and M. Scanlan and CV Jongeneel and MA Lagarkova and SA Nedospasov},
  journal={Genes and Immunity},
By serological screening of a breast tumor cDNA library we have identified a novel human gene, tnkl, encoding an ankyrin-related protein with a high degree of similarity to tankyrase, the poly(ADP-ribose)polymerase associated with human telomeres (Smith et al, Science 282: 1484). The tnkl gene maps to chromosome 10, while the tnks gene encoding tankyrase is located on chromosome 8. The predicted 1166-aa protein product of the tnkl gene is 78% identical to human tankyrase and 62% to a putative D… CONTINUE READING


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telomeric PARP, tankyrase, to nuclear pore complexes and centrosomes

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