Cloning and characterization of SmeT, a repressor of the Stenotrophomonas maltophilia multidrug efflux pump SmeDEF.

@article{Snchez2002CloningAC,
  title={Cloning and characterization of SmeT, a repressor of the Stenotrophomonas maltophilia multidrug efflux pump SmeDEF.},
  author={Patricia Cano S{\'a}nchez and Ana Alonso and Jos{\'e} Luis Mart{\'i}nez},
  journal={Antimicrobial agents and chemotherapy},
  year={2002},
  volume={46 11},
  pages={
          3386-93
        }
}
We report on the cloning of the gene smeT, which encodes the transcriptional regulator of the Stenotrophomonas maltophilia efflux pump SmeDEF. SmeT belongs to the TetR and AcrR family of transcriptional regulators. The smeT gene is located upstream from the structural operon of the pump genes smeDEF and is divergently transcribed from those genes. Experiments with S. maltophilia and the heterologous host Escherichia coli have demonstrated that SmeT is a transcriptional repressor. S1 nuclease… CONTINUE READING
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