Cloning and characterization of Sel-1l, a murine homolog of the C. elegans sel-1 gene

  title={Cloning and characterization of Sel-1l, a murine homolog of the C. elegans sel-1 gene},
  author={Dorit B. Donoviel and M. S Donoviel and Enguo Fan and A.-K Hadjantonakis and Alan Bernstein},
  journal={Mechanisms of Development},
The Notch signaling pathway regulates specification and proliferation in a variety of cell lineages in invertebrates and vertebrates. We have cloned a murine homolog of SEL-1, a key negative regulator of the Notch pathway in Caenorhabditis elegans. Murine SEL-1L (mSEL-1L) protein exhibits a high degree of similarity to SEL-1, including a signal peptide and the C-terminal region required for SEL-1 function in C. elegans. This mammalian homolog of sel-1 is widely expressed in adult mouse and… CONTINUE READING


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