Cloning and characterization of SK2 channel from chicken short hair cells

@article{Matthews2005CloningAC,
  title={Cloning and characterization of SK2 channel from chicken short hair cells},
  author={TM Matthews and R Duncan and Michael Zidanic and Th Michael and PA Fuchs},
  journal={Journal of Comparative Physiology A},
  year={2005},
  volume={191},
  pages={491-503}
}
In the inner ear of birds, as in mammals, reptiles and amphibians, acetylcholine released from efferent neurons inhibits hair cells via activation of an apamin-sensitive, calcium-dependent potassium current. The particular potassium channel involved in avian hair cell inhibition is unknown. In this study, we cloned a small-conductance, calcium-sensitive potassium channel (gSK2) from a chicken cochlear library. Using RT-PCR, we demonstrated the presence of gSK2 mRNA in cochlear hair cells… CONTINUE READING
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