Cloning and characterization of ALX, an adaptor downstream of CD28.

@article{Greene2003CloningAC,
  title={Cloning and characterization of ALX, an adaptor downstream of CD28.},
  author={Tiffani A. Greene and Penda Powell and Chima Nzerem and Michael Jeremy Shapiro and Virginia Smith Shapiro},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 46},
  pages={
          45128-34
        }
}
T cell activation requires two signals: specific recognition of antigen through the T cell receptor (TCR) and a costimulatory signal provided primarily by CD28 in naïve T cells. We cloned a novel gene with considerable homology to RIBP/TSAd/Lad, an adaptor involved in T cell activation and interleukin-2 (IL-2) promoter activation. Expression of this gene is limited to the spleen and thymus. We have named this gene ALX, adaptor in lymphocytes of unknown function X. Because the related adaptor… CONTINUE READING
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