Cloning and biological comparison of Restin, novel member of Mage superfamily

  title={Cloning and biological comparison of Restin, novel member of Mage superfamily},
  author={Zhongliang Zhao and Fangzhou Lu and Feng Zhu and Hui Yang and Yubo Chai and Sumin Chen},
  journal={Science in China Series C: Life Sciences},
In the present study, a new member of melanoma associated antigens (Mage), named Restin (219 amino acids), was identified from HL-60 cell induced by all-trans-retinoic acid (ATRA) by PCR-based subtractive hybridization. Bioinformatics analysis found this novel gene shares high homolog with Necdin (a neuronal growth suppressor, 49%). Both of them are basic proteins. Moreover, the Restin, Necdin and Mages are in one protein superfamily. This fact indicates that the Restin and Mages are mutually… CONTINUE READING


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