Cloning and analysis of the CYP1A promoter from the atlantic killifish (Fundulus heteroclitus).

@article{Powell2004CloningAA,
  title={Cloning and analysis of the CYP1A promoter from the atlantic killifish (Fundulus heteroclitus).},
  author={Wade H Powell and Hilary G. Morrison and E. Jennifer Weil and Sibel I. Karchner and Mitchell L. Sogin and John J. Stegeman and Mark E Hahn},
  journal={Marine environmental research},
  year={2004},
  volume={58 2-5},
  pages={119-24}
}
Enzymes in the cytochrome P450 gene family 1 (CYP1) catalyze the metabolic activation of numerous hydrocarbon carcinogens and various natural compounds. CYP1 family members have been identified in several vertebrates, including fish, amphibians, birds, and mammals, and are inducible by aromatic hydrocarbons acting through the aryl hydrocarbon receptor (AHR). Together with its heterodimeric partner ARNT, the ligand-bound AHR binds conserved xenobiotic response elements (XREs) near the promoter… CONTINUE READING

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