Cloning and Heterologous Expression of Three Type II PKS Gene Clusters from Streptomyces bottropensis

@article{Yan2012CloningAH,
  title={Cloning and Heterologous Expression of Three Type II PKS Gene Clusters from Streptomyces bottropensis},
  author={Xiaohui Yan and Katharina Probst and Anton Linnenbrink and M. Arnold and T. Paululat and A. Zeeck and A. Bechthold},
  journal={ChemBioChem},
  year={2012},
  volume={13}
}
  • Xiaohui Yan, Katharina Probst, +4 authors A. Bechthold
  • Published 2012
  • Biology, Medicine
  • ChemBioChem
  • Mensacarcin is a potent cytotoxic agent isolated from Streptomyces bottropensis. It possesses a high content of oxygen atoms and two epoxide groups, and shows cytostatic and cytotoxic activity comparable to that of doxorubicin, a widely used drug for antitumor therapy. Another natural compound, rishirilide A, was also isolated from the fermentation broth of S. bottropensis. Screening a cosmid library of S. bottropensis with minimal PKS‐gene‐specific primers revealed the presence of three… CONTINUE READING
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