Cloning and Characterization of a Potassium-Dependent Sodium/Calcium Exchanger in Drosophila

@article{HaugCollet1999CloningAC,
  title={Cloning and Characterization of a Potassium-Dependent Sodium/Calcium Exchanger in Drosophila},
  author={Kristin Haug-Collet and Bret Pearson and Rebecca Webel and R. T. Szerencsei and R J Winkfein and P Schnetkamp and Nicola Colley},
  journal={The Journal of Cell Biology},
  year={1999},
  volume={147},
  pages={659 - 670}
}
Sodium/calcium(-potassium) exchangers (NCX and NCKX) are critical for the rapid extrusion of calcium, which follows the stimulation of a variety of excitable cells. To further understand the mechanisms of calcium regulation in signaling, we have cloned a Drosophila sodium/calcium-potassium exchanger, Nckx30C. The overall deduced protein topology for NCKX30C is similar to that of mammalian NCKX, having five membrane-spanning domains in the NH(2) terminus separated from six at the COOH-terminal… CONTINUE READING

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