Cloning: Pathways to a Pluripotent Future

@article{Mclaren2000CloningPT,
  title={Cloning: Pathways to a Pluripotent Future},
  author={Anne Mclaren},
  journal={Science},
  year={2000},
  volume={288},
  pages={1775 - 1780}
}
In this month's essay, Anne McLaren traces the winding and pitted pathways that connect the early days of the cell theory of biology in the 1830s to the new and unfolding era of cloning science and technology that came to worldwide attention in 1997 with the announcement of the birth of Dolly, the Scottish cloned sheep. The possibilities, including the potential for new medical treatments and perhaps even human cloning, are fantastic ... and ethically charged. 
Mammalian cloning: advances and limitations
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Cloning by the transfer of nuclei from adult cells is still a hit-and-miss procedure, and the understanding of the molecular basis of reprogramming remains extremely limited and affects experimental approaches towards increasing the success rate of cloning.
Cloning, mitochondrial replacement and genome editing: 25 years of ethical debate since Dolly.
TLDR
It is suggested that many of the fundamental concerns about the possibility of human reproductive cloning that were precipitated by Dolly persist today in the arguments of those who oppose MRT and any use of heritable human genome editing (HHGE).
The first half-century of nuclear transplantation
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  • Biology
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  • 2003
TLDR
The eventual identification of reprogramming molecules and mechanisms could facilitate a route toward cell replacement therapy in humans.
The First Half-Century of Nuclear Transplantation
  • J. Gurdon, J. Byrne
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2003
TLDR
The eventual identification of reprogramming molecules and mechanisms could facilitate a route toward cell replacement therapy in humans.
Embryonale stamceller og terapeutisk kloning
TLDR
Increased interest in the therapeutic use of human stem cells has emerged following significant progress in ongoing research, and the discovery that adult stem cells may be reprogrammed taken together give substance to hopes that novel principles of treatment may be developed for a variety of serious conditions.
New techniques on embryo manipulation.
Cloning of Homo sapiens? No!
  • R. McKinnell
  • Biology
    Differentiation; research in biological diversity
  • 2002
Animal cloning by nuclear transplantation was first developed in the northern leopard frog, Rana pipiens. It was soon extended to other amphibian species and within time, to various mammalian
Impact of transgenic technologies on functional genomics.
TLDR
The origins and current status of transgenic technologies, various applications and technologies including chromosome engineering, stem cells, gene traps and modification of livestock are presented.
...
...

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TLDR
This is the first report, to the authors' knowledge, of live mammalian offspring following nuclear transfer from an established cell line, and will provide the same powerful opportunities for analysis and modification of gene function in livestock species that are available in the mouse through the use of embryonic stem cells.
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TLDR
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