Cloning, transport properties, and differential localization of two splice variants of GLT-1 in the rat CNS: implications for CNS glutamate homeostasis.

@article{Sullivan2004CloningTP,
  title={Cloning, transport properties, and differential localization of two splice variants of GLT-1 in the rat CNS: implications for CNS glutamate homeostasis.},
  author={Robert K P Sullivan and Thomas Rauen and Frauke Fischer and Michael Wiessner and Christof T Grewer and Ana Bicho and David V. Pow},
  journal={Glia},
  year={2004},
  volume={45 2},
  pages={
          155-69
        }
}
At least two splice variants of GLT-1 are expressed by rat brain astrocytes, albeit in different membrane domains. There is at present only limited data available as to the spatial relationship of such variants relative to the location of synapses and their functional properties. We have characterized the transport properties of GLT-1v in a heterologous expression system and conclude that its transport properties are similar to those of the originally described form of GLT-1, namely GLT-1alpha… CONTINUE READING
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