Cloning, structural organization and regulation of expression of the Penicillium chrysogenum paf gene encoding an abundantly secreted protein with antifungal activity.

@article{Marx1995CloningSO,
  title={Cloning, structural organization and regulation of expression of the Penicillium chrysogenum paf gene encoding an abundantly secreted protein with antifungal activity.},
  author={Florentine Marx and Hubertus Haas and Manfred Reindl and Georg St{\"o}ffler and Friedrich Lottspeich and Bernhard Redl},
  journal={Gene},
  year={1995},
  volume={167 1-2},
  pages={167-71}
}
An abundantly secreted, highly basic 12-kDa protein (PAF) was purified from the culture medium of Penicillium chrysogenum (Pc). Based on the N-terminal amino acid (aa) sequence of the protein, an oligodeoxyribonucleotide probe was derived and used for amplification of the encoding cDNA by PCR. This cDNA fragment encodes a Cys-rich preproprotein of 92 aa which appears to be processed to a mature product of 55 aa. The deduced aa sequence of the preproprotein reveals 42.6% identity to an… CONTINUE READING
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