Cloning, sequencing and expression of the human thyrotropin (TSH) receptor: evidence for binding of autoantibodies.

@article{Libert1989CloningSA,
  title={Cloning, sequencing and expression of the human thyrotropin (TSH) receptor: evidence for binding of autoantibodies.},
  author={Fr{\'e}d{\'e}rick Libert and Anne Lefort and Catherine G{\'e}rard and M. Parmentier and Jean-B. Perret and Marian Ludgate and Jacques E. Dumont and G. Vassart},
  journal={Biochemical and biophysical research communications},
  year={1989},
  volume={165 3},
  pages={
          1250-5
        }
}
A human thyroid cDNA library was screened by hybridization with a dog thyrotropin receptor (TSHr) cDNA. Sequencing of the resulting clones identified a 2292 residue open reading frame encoding a 744 amino acid mature polypeptide presenting 90.3% similarity with the dog TSHr. Two major transcripts (4.6 and 4.4 kilobases) were identified in the human thyroid which suggests that alternative splicing could generate multiple forms of human TSHr. Transfection of the coding sequence in COS-7 cells… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 59 CITATIONS, ESTIMATED 46% COVERAGE

Analysis of carbohydrate residues on recombinant human thyrotropin receptor.

  • The Journal of clinical endocrinology and metabolism
  • 1999
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Hormone Resistance Syndromes

  • Contemporary Endocrinology
  • 1999
VIEW 8 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

A Modifying Autoantigen in Graves' Disease.

  • Endocrinology
  • 2019
VIEW 2 EXCERPTS
CITES BACKGROUND

Graves' disease in clinical perspective.

VIEW 1 EXCERPT
CITES BACKGROUND

FILTER CITATIONS BY YEAR

1992
2019

CITATION STATISTICS

  • 5 Highly Influenced Citations