Cloning, sequencing and expression in the dog of the main amyloid precursor protein isoforms and some of the enzymes related with their processing.

@article{Sarasa2010CloningSA,
  title={Cloning, sequencing and expression in the dog of the main amyloid precursor protein isoforms and some of the enzymes related with their processing.},
  author={Leticia Sarasa and Cl{\'a}ribel Gallego and Inmaculada Monle{\'o}n and A Olvera and Jes{\'u}s Canudas and Mar{\'i}a Monta{\~n}{\'e}s and Pedro Pesini and M Arraiza Sarasa},
  journal={Neuroscience},
  year={2010},
  volume={171 4},
  pages={1091-101}
}
Alzheimer's disease (AD) is characterized by neuronal loss and the presence of both neurofibrillary tangles and senile plaques in the brain. These plaques arise from the deposition of beta-amyloid (Aβ) peptides (38-43 amino acids), which are generated from enzymatic cleavage of the amyloid precursor protein (APP) by β- and γ-secretases. In the present work… CONTINUE READING